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pentobarbital will minimize the extent or result of ripretinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.Check Closely (two)pentobarbital will decrease the extent or result of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Robust CYP3A4 inducers may perhaps reduce suvorexant efficacy;